| 8/31/24 |
 Olivet Nazarene |
L 14-35 |
Cardinal Stadium – Ann Arbor, MI |
| 9/7/24 |
 Defiance College |
W 34-10 |
Cardinal Stadium – Ann Arbor, MI |
| 9/14/24 |
 Marian University |
L 31-34 |
St. Vincent Field – Indianapolis, IN |
| 9/21/24 |
 University of St. Francis (Ill) |
L 7-44 |
Cardinal Stadium – Ann Arbor, MI |
| 9/28/24 |
 Saint Xavier University |
L 17-27 |
Bruce R. Deaton Memorial Field – Chicago, IL |
| 10/5/24 |
 Judson University |
W 45-6 |
Millennium Field – Streamwood, IL |
| 10/19/24 |
 Madonna University |
W 67-6 |
Cardinal Stadium – Ann Arbor, MI |
| 10/26/24 |
 Siena Heights University |
W 9-0 |
Cardinal Stadium – Ann Arbor, MI |
| 11/2/24 |
 Indiana Wesleyan |
L 24-48 |
Wildcat Stadium – Marion, IN |
| 11/9/24 |
 Lawrence Tech |
W 31-10 |
Cardinal Stadium – Ann Arbor, MI |
| 11/16/24 |
 Taylor University |
L 14-20 |
Cardinal Stadium – Ann Arbor, MI |
